SARS coronavirus papain-like protease up-regulates the collagen expression through non-Samd TGF-β1 signaling
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چکیده
منابع مشابه
SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-β1 via ROS/p38 MAPK/STAT3 pathway
SARS coronavirus (SARS-CoV) papain-like protease (PLpro) has been identified in TGF-β1 up-regulation in human promonocytes (Proteomics 2012, 12: 3193-205). This study investigates the mechanisms of SARS-CoV PLpro-induced TGF-β1 promoter activation in human lung epithelial cells and mouse models. SARS-CoV PLpro dose- and time-dependently up-regulates TGF-β1 and vimentin in A549 cells. Dual lucif...
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ژورنال
عنوان ژورنال: Virus Research
سال: 2017
ISSN: 0168-1702
DOI: 10.1016/j.virusres.2017.04.008